Program	Molecule	Potential indications
SARM1 inhibition	SIR2501	Neurodegenerative diseases
NAMPT activation	SIR4156	Neuronal and muscular degenerative diseases
RIPK1 inhibition	SIR9900	Inflammation & Immunology
	SIR2446	diseases, traumatic CNS conditions
Undisclosed	SIR8752	Inflammation & Immunology diseases
Brain Delivery Module	Therapeutic target / BDM	Neurodegenerative diseases
Early-stage programs